%0 Journal Article
%T Rela£¿£¿o entre a esfericidade, a fun£¿£¿o ventricular e o tamanho do infarto em ratos
%A Minicucci
%A Marcos F.
%A Azevedo
%A Paula S.
%A Matsubara
%A Beatriz B.
%A Matsubara
%A Luiz S.
%A Paiva
%A Sergio A. R.
%A Zornoff
%A Leonardo A. M.
%J Arquivos Brasileiros de Cardiologia
%D 2010
%I Sociedade Brasileira de Cardiologia - SBC
%R 10.1590/S0066-782X2010005000023
%X background: the left ventricular (lv) sphericity is a factor associated with ventricular dysfunction, but it is not well-characterized in the experimental infarction model in rats. objective: to analyze the association between the sphericity index (si), the ventricular function and the infarcted area in an experimental rat model. methods: six months after the infarction (ami, n=33) or simulated surgery (sham, n=18), the animals were submitted to an echocardiogram. the si was obtained through the ratio between the diastolic areas at the lv long axis and the short axis. results: the ami group presented the lowest index of sphericity (1.32 ¡Á 0.23 vs 1.57 ¡Á 0.33; p=0.002), systolic function and relative thickness (0.13 ¡Á 0.003 vs 0.18 ¡Á 0.04; p<0.001) and the highest index of parietal stress (1.27 ¡Á 0.33 vs 0.88 ¡Á 0.25; p<0.001). there was a significant correlation between the infarct size and sphericity (p=0.046). at the linear regression analysis, the infarct size (p=0.014), but not the sphericity (p=0.683) and the parietal stress (p=0.176), was the predictive factor of the systolic function. eccentric remodeling (p=0.011), but not sphericity (p=0.183) or the infarct size (p=0.101), was a predictive factor of parietal stress. additionally, the infarct size (p=0.046), but not the eccentric remodeling (0.705), was a predictive factor of sphericity. the infarct size (p=0.015) and the parietal stress (p=0.011), but not the sphericity (p=0.705), were the predictors of eccentric remodeling. conclusion: the sphericity is associated, but it is not a determinant factor of parietal stress, of eccentric remodeling and ventricular systolic function in an experimental infarction model in rats.
%K myocardial infarction
%K rats
%K ventricular function.
%U http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0066-782X2010000500012&lng=en&nrm=iso&tlng=en