%0 Journal Article
%T Redu£¿£¿o da densidade de extrass¨ªstoles e dos sintomas relacionados ap¨®s administra£¿£¿o de magn¨¦sio por via oral
%A Falco
%A Cristina N¨¢dja Muniz Lima De
%A Grupi
%A Cesar
%A Sosa
%A Eduardo
%A Scanavacca
%A Maur¨ªcio
%A Hachul
%A Denise
%A Lara
%A Sissy
%A Sacilotto
%A Luciana
%A Pisani
%A Cristiano F.
%A Ramires
%A Jos¨¦ A. F.
%A Darrieux
%A Francisco
%J Arquivos Brasileiros de Cardiologia
%D 2012
%I Sociedade Brasileira de Cardiologia - SBC
%R 10.1590/S0066-782X2012005000043
%X background: premature ventricular and supraventricular complexes (pvc and psvc) are frequent and often symptomatic. the magnesium (mg) ion plays a role in the physiology of cell membranes and cardiac rhythm. objective: we evaluated whether the administration of mg pidolate (mgp) in patients with pvc and psvc is superior to placebo (p) in improving symptoms and arrhythmia frequency. methods: randomized double-blind study with 60 consecutive symptomatic patients with more than 240 pvc or psvc on 24-hour holter monitoring who were selected to receive placebo or mgp. to evaluate symptom improvement, a categorical and a specific questionnaire for symptoms related to pvc and psvc was made. improvement in premature complex density (pcd) per hour was considered significant if percentage reduction was >70% after treatment. the dose of mgp was 3.0 g/day for 30 days, equivalent to 260mg of mg element. none of the patients had structural heart disease or renal failure. results: of the 60 patients, 33 were female (55%). ages ranged from 16 to 70 years old. in the mgp group, 76.6% of patients had a pcd reduction >70%, 10% of them >50% and only 13.4% <50%. in the p group, 40% showed slight improvement, <30%, in the premature complexes frequency (p < 0.001). symptom improvement was achieved in 93.3% of patients in the mgp group, compared with only 16.7% in the p group (p < 0.001). conclusion: oral mg supplementation decreases pcd, resulting in symptom improvement.
%K arrhythmias
%K cardiac
%K ventricular premature complexes
%K magnesium
%K ion channels.
%U http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0066-782X2012005000043&lng=en&nrm=iso&tlng=en