%0 Journal Article
%T Estudio de la funci¨®n endotelial mediante tomograf¨ªa por emisi¨®n de positrones en pacientes con hipercolesterolemia
%A Alex¨¢nderson Rosas
%A Erick
%A Meave Gonz¨¢lez
%A Aloha
%A Garc¨ªa-Rojas Castillo
%A Leonardo
%A Rodr¨ªguez Valero
%A M¨®nica
%A Lamothe Molina
%A Pedro Alberto
%A Talayero Petra
%A Jos¨¦ Antonio
%A Sierra Fern¨¢ndez
%A Carlos
%A Cruz Garc¨ªa-Villa
%A Patricio
%A Rodr¨ªguez Zanella
%A Hugo Gerardo
%A Barrera P¨¦rez
%A Mar¨ªa
%A Carrera Cer¨®n
%A Roc¨ªo Elisa
%A Calleja Torres
%A Rodrigo
%A Mart¨ªnez Garc¨ªa
%A Alfonso
%A Ricalde Alcocer
%A Alejandro
%A Romero Ibarra
%A Jos¨¦ Luis
%A Alex¨¢nderson Rosas
%A Graciela
%J Archivos de cardiolog¨ªa de M¨¦xico
%D 2008
%I Scientific Electronic Library Online
%X hypercholesterolemia prompts to endothelial dysfunction (ed) and ed predisposes to atherogenesis. ed appears early in the course of atherogenesis and it is considered a coronary artery disease (cad) marker. objectives: to assess endothelial function (ef) using positron emission tomography (pet) in asymptomatic patients with recent dyslipidemia diagnosis and without history of ischemic heart disease and previous hypolipemiant treatment. material and methods: fourteen asymptomatic patients with recent dyslipidemia diagnosis (< 6 months) were studied by obtaining a lipid profile, blood glucose, and a three phase 13n-ammonia pet scan: rest, cold pressortest (cpt) and pharmacologic stress with adenosine. ef was assessed by calculating the coronary flow reserve (cfr), endothelial-dependant vasodilatation index (edvi), and coronary blood flow increase percentage in cpt (% ¦Ä cf). results: 79% of patients with dyslipidemia had ed and all their values were lower than those previously published as normal: rest coronary flow 0.44 ¡À 0.12 vs 0.57 ¡À 0.147 (p = 0.002), cpt coronary flow 0.57 ¡À 0.17 vs 0.88 ¡À 0.26 (p = 0.001), stress coronary flow 1.24 ¡À 0.05 vs 1.81 ¡À 0.35 (p = 0.005), edv11.28 ¡À 0.25 vs 1.53 ¡À 0.24 (p 0.017), crf 2.79 ¡À 0.94 vs 3.15 ¡À 0.48 (p 0.198) and % ¦Ä cf 29.08 ¡À 24.62% vs 53 ¡À 24.60% (p 0.022). conclusions: asymptomatic patients in early stages of dyslipidemia showed a greater ed prevalence that was detected by 13n-ammonia pet scan.
%K positron emission tomography
%K endothelial dysfunction
%K dyslipidemia.
%U http://www.scielo.org.mx/scielo.php?script=sci_abstract&pid=S1405-99402008000200003&lng=en&nrm=iso&tlng=en