%0 Journal Article
%T Evaluaci¨®n del efecto de carvedilol en ni£¿os con cardiomiopat¨ªa dilatada
%A Balderr¨¢bano Saucedo
%A Norma Alicia
%A Vizca¨ªno Alarc¨®n
%A Alfredo
%A Espinosa Islas
%A Gonzalo
%A Reyes De La Cruz
%A Lorenzo
%J Archivos de cardiolog¨ªa de M¨¦xico
%D 2008
%I Scientific Electronic Library Online
%X objective: to evaluate the effect of carvedilol administrated during 8 months in children with heart failure secondary to dilated cardiomyopathy. methods: we initiated carvedilol in patients who, despite optimization of standard treatment, had persistent left ventricular ejection fraction < 40% and evaluated the systolic and diastolic left ventricular function before and after 4 and 8 months of treatment. results: 19 patients were included in the study, 10 women; median age: 6.7 years and 17 ¡À 12.4 months after the diagnosis. the ejection fraction improved significantly from entry to eight months (median: 33.5 to 52.6%, p = 0.01) as did the shortening fraction (m: 14.8 to 25.8%, p = 0.01). the myocardial performance index abnormal in all 19 patients became normal in 5 at the end of study. in addition mitral doppler flow which was altered in 9 improved in 3 and pulmonary venous flow abnormal in all patients improved in 13. only 1 patient presented minimal adverse effects. conclusions: carvedilol added to standard therapy for dilated cardiomyopathy improves left ventricular function, is well tolerated, and has minimal adverse effects in childhood.
%K heart failure
%K dilated cardiomyopathy
%K left ventricular function.
%U http://www.scielo.org.mx/scielo.php?script=sci_abstract&pid=S1405-99402008000100006&lng=en&nrm=iso&tlng=en