%0 Journal Article
%T In vivo assessment of hemocompatibility of a ventricular assist device in healthy swine
%A Sacrist¨¢n
%A Catarina
%A Escobedo
%A Carlos R.
%A Bojalil
%A Rafael
%A Izaguirre
%A Ra¨²l A.
%A Cortina
%A Evelyn
%A Aranda
%A Alberto
%A Catrip
%A Jorge
%A Lespr¨®n
%A Ma del Carmen
%A Springall
%A Rashidi
%A Sacrist¨¢n
%A Emilio
%J Archivos de cardiolog¨ªa de M¨¦xico
%D 2010
%I Scientific Electronic Library Online
%X objective: to assess the hemocompatible performance of a novel implantable pneumatic ventricular assist device (vad, innovam¨¦dica, m¨¦xico) in healthy swine. the aim of this pilot study was first, to determine if short-term vad implantation elicited a remarkable inflammatory response above that expected from surgical trauma; and second, to assess if heparinized or passivated vad coatings, in combination with systemic anticoagulant or antiaggregant therapies, modified the vad's hemocompatible performance. methods: hemodynamic, physiologic, inflammatory and histological parameters were measured in 27 pigs receiving vad support for six hours, testing combinations of heparinized or passivated vad coatings and systemic anticoagulant/ antiaggregant therapies. mean concentrations of interleukin-1 ¦Â (il-16), interleukin-6 (il-6), c-reactive protein (crp), or thrombin-antithrombin iii (tat) complexes (coagulation indicator) were measured from blood. anova statistics were employed. results: no substantial increases in mean il-1¦Â, il-6, crp, or tat were obtained during vad support. hemodynamic and physiologic parameters were normal. we found no evidence of thromboembolisms or micro-infarctions in heart and lung samples. no major coaguli/deposits were found in vad compartments. overall, no remarkable differences in measurements were found using heparinized, passivated, or uncoated vad, or with systemic anticoagulation, antiaggregant therapy, or no treatment. conclusions: our findings demonstrate, firstly, that during the time-period tested, the vad elicited negligible inflammation above the effects of surgical trauma; and secondly, that little coagulation was observed upon vad support in any of the cases tested. contemplating further validation studies, our data indicate that the innovam¨¦dica vad is a highly hemocompatible system.
%K ventricular assist device
%K circulatory support
%K hemocompatibility
%K inflammation
%K swine
%K mexico.
%U http://www.scielo.org.mx/scielo.php?script=sci_abstract&pid=S1405-99402010000200002&lng=en&nrm=iso&tlng=en