%0 Journal Article %T Cardiolog¨ªa "basada en la evidencia": aplicaciones pr¨¢cticas de la epidemiolog¨ªa. II. El uso de biomarcadores %A Trejo-Guti¨¦rrez %A Jorge F. %A L¨®pez-Jim¨¦nez %A Francisco %J Archivos de cardiolog¨ªa de M¨¦xico %D 2011 %I Scientific Electronic Library Online %X the use of biomarkers that show an association with the development of cardiovascular disease needs a careful evaluation in regard to the quality of evidence that establishes their relationship. although observational studies have been paramount to establish the importance of the traditional risk factors, we can only screen and intervene on biomarkers when there is demonstrated benefit in well-designed randomized clinical trials. %K biomarkers %K observational studies %K randomized controlled trials %K usa. %U http://www.scielo.org.mx/scielo.php?script=sci_abstract&pid=S1405-99402011000200013&lng=en&nrm=iso&tlng=en