%0 Journal Article
%T CD4+, CD8+ and CD4- CD8- T cell-subsets can confer protection against Leishmania m. mexicana infection
%A Lezama-D¨¢vila
%A C. M
%A Gallagher
%A G
%J Mem¨®rias do Instituto Oswaldo Cruz
%D 1995
%I Instituto Oswaldo Cruz, Minist¨¦rio da Sa¨²de
%R 10.1590/S0074-02761995000100012
%X we studied the role of cd4+, cd8+, cd4- cd8- t cells and igg anti-leishmania after infection or vaccination in the cba/ca mouse. mice were either infected with l. m. mexicana promastigotes or vaccinated with parasite-membrane antigens incorporated into liposomes. successfully vaccinated mice were used as cell-donors in adoptive transfer experiments. naive, syngeneic recipients received highly-enriched cd4+, cd8+ or cd4- cd8- t cells from those two set of donors and challenged with live parasites. our results showed that, both cd4+ and cd8+ t cells from infected or vaccinated donors conferred significant disease-resistance to naive recipients. in addition, adoptive transfer of cd4- cd8- t cells from vaccinated donors significantly delayed lesion growth in recipient mice. we concluded that vaccination of cba mice correlates with the induction of protective cd4+, cd8+ and cd4- cd8- t cells and the synthesis of igg anti-leishmania.
%K t cell-subpopulations
%K leishmania m. mexicana
%K liposomes monoclonal antibodies.
%U http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0074-02761995000100012&lng=en&nrm=iso&tlng=en