%0 Journal Article
%T Hepatitis B virus infection profile in hemodialysis patients in Central Brazil: prevalence, risk factors, and genotypes
%A Ferreira
%A Renata C
%A Teles
%A Sheila A
%A Dias
%A M¨˘rcia A
%A Tavares
%A Viviane R
%A Silva
%A Simonne A
%A Gomes
%A Selma A
%A Yoshida
%A Clara FT
%A Martins
%A Regina MB
%J Mem¨®rias do Instituto Oswaldo Cruz
%D 2006
%I Instituto Oswaldo Cruz, Minist¨¦rio da Sa¨˛de
%R 10.1590/S0074-02762006000600019
%X hemodialysis patients are at high risk for hepatitis b virus (hbv) infection. a survey was conducted in the hemodialysis population of the state of goi¨˘s, central brazil, aiming to assess the prevalence of hbv infection, to analyse associated risk factors, and also to investigate hbv genotypes distribution. a total of 1095 patients were interviewed in 15 dialysis units. serum samples were screened for hbv serological markers by enzyme-linked immunosorbent assay. hepatitis b surface antigen (hbsag) positive samples were tested for hbv dna by polymerase chain reaction and genotyped by restriction fragment length polymorphism. global hbv infection prevalence was 29.8% (95% ci: 27.1-32.5). multivariate analysis of risk factors showed that male gender, length of time on hemodialysis, and blood transfusion before 1993 were associated with hbv positivity. hbv dna was detected in 65.4% (17/26) of the hbsag-positive samples. thirteen of 17 hbv dna positive samples were genotyped. genotype d (61.5%) was predominant, followed by a (30.8%), while genotype f was detected in only one (7.7%) sample.
%K hepatitis b virus
%K hemodialysis
%K central brazil.
%U http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0074-02762006000600019&lng=en&nrm=iso&tlng=en