%0 Journal Article
%T An Ethanol Extract of Artemisia iwayomogi Activates PPAR¦Ä Leading to Activation of Fatty Acid Oxidation in Skeletal Muscle
%A Si Young Cho
%A Hyun Woo Jeong
%A Jong Hee Sohn
%A Dae-Bang Seo
%A Wan Gi Kim
%A Sang-Jun Lee
%J PLOS ONE
%D 2012
%I Public Library of Science (PLoS)
%R 10.1371/journal.pone.0033815
%X Although Artemisia iwayomogi (AI) has been shown to improve the lipid metabolism, its mode of action is poorly understood. In this study, a 95% ethanol extract of AI (95EEAI) was identified as a potent ligand of peroxisome proliferator-activated receptor¦Ä (PPAR¦Ä) using ligand binding analysis and cell-based reporter assay. In cultured primary human skeletal muscle cells, treatment of 95EEAI increased expression of two important PPAR¦Ä-regulated genes, carnitine palmitoyl-transferase-1 (CPT1) and pyruvate dehydrogenase kinase isozyme 4 (PDK4), and several genes acting in lipid efflux and energy expenditure. Furthermore, 95EEAI stimulated fatty acid oxidation in a PPAR¦Ä-dependent manner. High-fat diet-induced obese mice model further indicated that administration of 95EEAI attenuated diet-induced obesity through the activation of fatty acid oxidation in skeletal muscle. These results suggest that a 95% ethanol extract of AI may have a role as a new functional food material for the prevention and/or treatment of hyperlipidermia and obesity.
%U http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0033815