%0 Journal Article
%T La prote¨ªna asociada a SLAM (SAP) regula la expresi¨®n de IFN-g en lepra
%A Quiroga
%A Mar¨ªa F.
%A Mart¨ªnez
%A Gustavo J.
%A Pasquinelli
%A Virginia
%A Garc¨ªa
%A Ver¨®nica E.
%J Medicina (Buenos Aires)
%D 2004
%I Fundaci¨®n Revista Medicina
%X tuberculoid leprosy patients locally produce th1 cytokines, while lepromatous patients produce th2 cytokines. signaling lymphocytic activation molecule (slam) and the slam-associated protein (sap) participate in the differentiation process that leads to the production of specific patterns of cytokines by activated t cells. to investigate the slam/sap pathway in m. leprae infection, we determined the expression of sap, ifn-g and slam rna messenger in leprosy patients. we found a direct correlation of slam expression with ifn-g expression, whereas the expression of sap was inversely correlated with the expression of both slam and ifn-g. therefore, our data indicate that sap might interfere with th1 cytokine responses while slam expression may contribute to th1 responses in leprosy. this study further suggests that the slam/sap pathway might be a focal point for therapeutic modulation of t cell cytokine responses in diseases characterized by dysfunctional th2 responses.
%K th1
%K sap
%K slam
%K ifn-g
%K co-stimulation
%K intracellular infection.
%U http://www.scielo.org.ar/scielo.php?script=sci_abstract&pid=S0025-76802004000500010&lng=en&nrm=iso&tlng=en