%0 Journal Article
%T Progresi¨®n de la Poliquistosis renal autos¨®mica dominante: Influencia de polimorfismos de genes de sintasa endotelial del ¨®xido n¨ªtrico (ecNOS) y del sistema renina-angiotensina
%A Azurmendi
%A Pablo
%A Fraga
%A Adriana
%A Muchnik
%A Carolina
%A dos Ramos Farias
%A Maria
%A Galan
%A Felicita
%A Guerra
%A Danisa
%A O'Flaherty
%A Martin
%A Arrizurieta
%A Elvira
%A Martin
%A Rodolfo
%J Medicina (Buenos Aires)
%D 2004
%I Fundaci¨®n Revista Medicina
%X glomerular filtration rate decline (gfrd) is variable in autosomic dominant polycystic kidney disease (adpkd). in 88 adpkd patients, gfrd was assessed by 1/scr and compared with the association to at1a1166c (at1r), agtm235t (angiotensinogen) and ecnosglu298asp (no endothelial synthase) polymorphisms. age at scr values of 2 and 6 mg/dl were assumed as beginning of progressive phase (a2) and end-stage-renal disease (a6), respectively. polymorphisms were studied by pcr-rflp. the group as a whole showed gfrd (ml/min/year) of 6.9¡À0.5; a2 and a6 of 48.9¡À1.3 and 55.0¡À1.4 years and mean arterial pressure of 111.2¡À1.2 mmhg. when a6 was considered, two populations were defined (¡ê and > 55 years). in ¡ê 55 (assumed as pkd1 phenotype) (n=42), a2 and a6 of the at11166cc genotype were 36.0¡À1.2 and 41.4¡À0.9 years vs aa-ac (42.8¡À1.0 and 47.5¡À0.8, p<0.001). a2 and a6 of the ecnos298asp/asp genotype were 34.8¡À1.5 and 41.1¡À0.6 years vs. glu/glu-glu/asp (42.4¡À0.9 and 47.1¡À0.8, p<0.02). in agt235tt genotype, gfrd was 12.4¡À2.2 ml/min/year vs mm-mt (7.9¡À0.7, p<0.03). this difference was also observed when all adpkd patients were considered (tt: 11.02¡À1.5 vs. mm-mt: 6.44¡À0.5 ml/min/year, p<0.003). at1 1166cc and ecnos 298asp/asp are associated with earlier a2 and a6 whereas agt 235tt induce twofold increase in gfrd, suggesting that ras and ecnos are involved in adpkd progression.
%K gfr decline
%K adpkd
%K at1a1166c
%K agtm235t
%K ecnosglu298asp.
%U http://www.scielo.org.ar/scielo.php?script=sci_abstract&pid=S0025-76802004000200009&lng=en&nrm=iso&tlng=en