%0 Journal Article
%T Rho GTPasas como blancos terap¨¦uticos relevantes en c¨¢ncer y otras enfermedades humanas
%A Lorenzano Menna
%A Pablo
%A Cardama
%A Georgina A.
%A Comin
%A Mar¨ªa J.
%A Alonso
%A Daniel F.
%A G¨®mez
%A Daniel E.
%J Medicina (Buenos Aires)
%D 2010
%I Fundaci¨®n Revista Medicina
%X rho gtpases are a key protein family controlling the transduction of external signals to cytoplasmatic and nuclear effectors. in the last few years, the development of genetic and pharmacological tools has allowed a more precise definition of the specific roles of rho gtpases. the aim of this review is to describe the cellular functions regulated by these proteins with focus on the molecular mechanism involved. we also address the role of rho gtpases in the development of different human diseases such as cancer. finally, we describe different experimental therapeutic strategies with rho gtpases as molecular targets.
%K cell signaling
%K cytoskeleton
%K cell migration
%K neurodegenerative diseases
%K cancer.
%U http://www.scielo.org.ar/scielo.php?script=sci_abstract&pid=S0025-76802010000600015&lng=en&nrm=iso&tlng=en