%0 Journal Article
%T Osteomalacia por tumor secretor de FGF-23
%A S¨¢nchez
%A Ariel
%A Castiglioni
%A Alejandro
%A C¨®ccaro
%A Nicol¨¢s
%A Silva
%A Roberto
%A Bobrovsky
%A Eduardo
%A Moys¨¦s
%A Rosa M.A.
%A Graciolli
%A Fabiana
%J Medicina (Buenos Aires)
%D 2013
%I Fundaci¨®n Revista Medicina
%X a case of oncogenic osteomalacia in a 50-year-old male is here presented. he suffered severe bone pain and marked muscular weakness of 4 years' duration. there were several vertebral deformities in the thoracic spine, bilateral fractures of the iliopubic branches, another fracture in the left ischiopubic branch, and a looser's zone in the right proximal tibia. an octreotide-tc scan allowed to identify a small tumor in the posterior aspect of the right knee. it was surgically removed. microscopically, it was a phosphaturic mesenchymal tumor-mixed connective tissue (pmt-mct). expression of fgf-23 was documented by immune-peroxidase staining. there was rapid improvement, with consolidation of the pelvic fractures and the tibial pseudo-fracture. the laboratory values returned to normal.
%K oncogenic osteomalacia
%K tumor-induced osteomalacia
%K hypophosphatemia
%K phosphaturic mesenchymal tumors
%K fgf-23.
%U http://www.scielo.org.ar/scielo.php?script=sci_abstract&pid=S0025-76802013000100009&lng=en&nrm=iso&tlng=en