%0 Journal Article
%T Aspectos gen¨¦ticos, cl¨ªnicos y fisiopatol¨®gicos del S¨ªndrome Metab¨®lico
%A Schnell
%A Mercedes
%A Dominguez
%A Zury A
%A Carrera
%A Carlos
%J Anales Venezolanos de Nutrici¨®n
%D 2007
%I Scientific Electronic Library Online
%X metabolic syndrome (ms) was described in 1988 to identify high cardiovascular risks patients, being obesity an important component of this syndrome. industrialization allowed changes in life style: lower physical activity, a change in the dietary pattern leading to a high calorie, high fat diet with a low dietary fiber content. from an evolutionary point of view "thrifty" genes were selected at a time when food resources were scarce, to grant the necessary metabolic changes in order to accumulate muscular glycogen and triglycerides in adipose tissue during difficult periods. it was proposed that these adaptations only became detrimental when this genetic pool is confronted with a nutrient abundant environment, which leads to an increased risk to develop non transmissible chronic diseases. the diagnostic criteria for metabolic syndrome are: abdominal obesity, hipertriglyceridemia, low plasma hdl and hyperglycemia. this review stresses the importance of abdominal obesity in the generation of cardiovascular disease and also insulin resistance in the metabolic syndrome. a reference to discrepancies in the cutoff values of different variables used to diagnose the ms is made and its importance is discussed. brief comments on the pathophysiology of the ms are included and the importance of the diagnosis and further research on ms in order to prevent cardiovascular disease is mentioned.
%K metabolic syndrome
%K obesity
%K genetics
%K insulin resistance
%K cardiovascular disease
%K abdominal circumference.
%U http://www.scielo.org.ve/scielo.php?script=sci_abstract&pid=S0798-07522007000200006&lng=en&nrm=iso&tlng=en