%0 Journal Article
%T Los prostanoides, una revoluci¨®n autacoide
%A Dominguez
%A Zury
%J Anales Venezolanos de Nutrici¨®n
%D 2006
%I Scientific Electronic Library Online
%X from 1960 to the end of the xx century, efforts from different laboratories were done to understand the regulation of eicosanoids biosynthesis and metabolism. these autacoids are synthesized from 20 c polyunsaturated fatty acids, from where they got the prefix eico, twenty. the physiologic and in certain conditions pathphysiologic actions, requires ¡Ü mmolar concentrations remaining active for periods of time ranging from seconds to minutes. during this productive period of the xx century it was possible to identify: 1- araquidonic acid as the main eicosanoid£¿s precursor, 2- the membrane phospholipids compartment as the cellular storage of the precursor fatty acid and 3- the phospholipases as the enzymes required to liberate the precursor fatty acid rending possible its access to the eicosanoids biosynthetic machinery. two main groups of eicosanoids arrive on the scene, classified in function to its molecular structure, one that includes the cyclic or prostanoids, where the prostaglandin h (pgh) is the universal precursor, pgh is a cyclic endoperoxide synthesized by the enzyme prostaglandin endoper¨®xido synthase, better known by its acronym cox for cycloxygenase, and the other, linear eicosanoids:: leukotrienes, lypoxines, and epoxides which are products synthesized from different enzymatic pathways including the lypoxygenase and cytochrome oxidases. the most relevant findings in the history of the prostanoids are considered in this review.
%K eicosanoids
%K prostanoids
%K w3 fatty acid
%K isoeicosanoids.
%U http://www.scielo.org.ve/scielo.php?script=sci_abstract&pid=S0798-07522006000200004&lng=en&nrm=iso&tlng=en