%0 Journal Article
%T Hormone profile of menopausal women in Havana
%A Navarro
%A Daysi
%A Acosta
%A Alina
%A Robles
%A Erick
%A D¨ªaz
%A C¨®ssette
%J MEDICC Review
%D 2012
%I Medical Education Cooperation with Cuba (MEDICC)
%R 10.1590/S1555-79602012000200005
%X introduction: there is a tendency among women today to delay the age at which they have their first child or subsequent children. this creates a dilemma for couples, since health professionals tend to counsel against pregnancy in women aged >40 years without considering their reproductive potential and their ability to and likelihood of conceiving and carrying to term a healthy newborn at little or no risk. objective: assess hypothalamic-pituitary-gonadal axis function in menopausal women in havana, to evaluate relevance to reproductive potential. methods: a retrospective study was conducted from march 2006 through march 2008 of 230 healthy women aged 40-59 years seen in the menopause and osteoporosis clinic in havana, cuba. chart review yielded data on current age, stage of climacteric and hormone levels expressed in means and standard deviations: serum follicle-stimulating hormone (fsh), luteinizing hormone (lh), estradiol and testosterone. analysis of variance was used for assesment by age group and stage of menopause (eumenorrheic, perimenopausal and postmenopausal), with a p value of <0.05 set as significance level. results: mean serum hormone levels in eumenorrheic women were: fsh 6.97 iu/l, lh 4.23 iu/l and estradiol 314 pmol/l; in perimenopausal women: fsh 34.69 iu/l, lh 20.78 iu/l and estradiol 201 pmol/l; and in postmenopausal women: fsh 75.43 iu/l, lh 37.59 iu/l and estradiol 117 pmol/l (p <0.05 for difference between eumenorrheic and postmenopausal women). there was a progressive increase in fsh and lh and a decline in estradiol with older age. there was no significant difference in testosterone levels by age or stage of menopause. conclusions: menstrual cycle and hormonal levels of the hypothalamic-pituitary-gonadal axis should be considered in addition to chronological age when determining reproductive potential in women aged 40-59 years.
%K hormones
%K hypothalamo-hypophyseal system
%K luteinizing hormone
%K follicle stimulating hormone
%K estradiol
%K testosterone
%K sex hormones
%K infertility
%K female
%K middle age
%K menopause
%K fertility
%K climacteric
%K cuba.
%U http://www.scielosp.org/scielo.php?script=sci_abstract&pid=S1555-79602012000200005&lng=en&nrm=iso&tlng=en