%0 Journal Article
%T Doen£¿a de Dowling-Degos: apresenta£¿£¿o cl¨ªnica e histopatol¨®gica cl¨¢ssica
%A Zimmermann
%A Carolina Cotta
%A Sforza
%A Deborah
%A Macedo
%A Priscila Marques de
%A Azulay-Abulafia
%A Luna
%A Alves
%A Maria de Fatima G. S
%A Carneiro
%A Sueli Coelho da S
%J Anais Brasileiros de Dermatologia
%D 2011
%I Sociedade Brasileira de Dermatologia
%R 10.1590/S0365-05962011000500016
%X dowling-degos disease (ddd) is a rare genetic disease of the skin (reticulate pigmented anomaly), clinically characterized by flexural brown pigmented reticulate macules, comedo-like papules on the back, neck and pitted perioral or facial scars. we present the case of a 51 year-old man with macrocomedo-like lesions, pitted scars, cysts, hyperpigmented macules in his back, chest, axillae, neck, groin and face. the patient reported having two children, three brothers and a father with a similar condition. the histopathology of the skin biopsies was very characteristic of dowling-degos disease, showing dilated follicular, fingerlike projections called rete ridges (dermal pegs), with thinning of the suprapapillary plates, resulting in an "antler-like" pattern and increased pigmentation of the basal layer.
%K hyperpigmentation
%K keratin-5
%K skin diseases
%K genetic.
%U http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0365-05962011000500016&lng=en&nrm=iso&tlng=en