%0 Journal Article
%T S¨ªndrome de restaura£¿£¿o imune associada ¨¤ histoplasmose
%A Passos
%A Leny
%A Talhari
%A Carolina
%A Santos
%A Monica
%A Ribeiro-Rodrigues
%A Rodrigo
%A Ferreira
%A Luiz Carlos de Lima
%A Talhari
%A Sinesio
%J Anais Brasileiros de Dermatologia
%D 2011
%I Sociedade Brasileira de Dermatologia
%R 10.1590/S0365-05962011000700044
%X a 27-year-old hiv-positive male patient with disseminated cutaneous histoplasmosis was treated with both haart and amphotericin b (total accumulated dose of 0.5g). amphotericin b was later replaced with itraconazole (200mg/day). two months after therapy had been started and the cutaneous lesions had healed, the patient interrupted both treatments voluntarily and his health deteriorated. haart was then re-introduced and cd4+ cell count increased sharply at the same time as lymph node histoplasmosis was diagnosed. this paradoxical response? the relapse of histoplasmosis and concomitant increase in cd4+ cell count and undetectable viral load after resumption of haart ? suggests that this was a case of immune reconstitution inflammatory syndrome (iris)
%K histoplasma
%K histoplasmosis
%K polymerase chain reaction.
%U http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0365-05962011000700044&lng=en&nrm=iso&tlng=en