%0 Journal Article
%T Dapsona como alternativa no tratamento de urtic¨¢ria cr£¿nica n£¿o responsiva a anti-histam¨ªnicos
%A Pires
%A Juliana Soares
%A Ue
%A Ana Paula Fusel de
%A Furlani
%A Wellington de Jesus
%A Souza
%A Patr¨ªcia Karla de
%A Rotta
%A Osmar
%J Anais Brasileiros de Dermatologia
%D 2008
%I Sociedade Brasileira de Dermatologia
%R 10.1590/S0365-05962008000500003
%X background: chronic urticaria is a dermatosis that negatively interferes in quality of life of affected individuals. the classic treatment with antihistamines is many times ineffective. objective: to evaluate the efficacy and safety of using dapsone in the treatment of chronic urticaria non-responsive to antihistamines. methods: a retrospective study was carried out by reviewing the medical charts of patients seen at an outpatient£¿s clinic specialized in urticaria, between november 1996 and march 2007. results: twenty patients with difficult to control chronic urticaria and who were treated with 100 mg/day of dapsone were evaluated. high doses of antihistamines were maintained and associated with dapsone. antihistamines alone did not control symptoms. fourteen patients (70%) presented good results, observed in the reduction or disappearance of lesions as well as in reduced pruritus; three patients (15%) did not get any success with the medication; and three (15%) had the treatment interrupted due to side effects. conclusion: in this study it can be concluded that dapsone is a safe and efficient option for patients presenting severe chronic urticaria non-responsive to antihistamines.
%K dapsone
%K histamine h1 antagonists
%K urticaria.
%U http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0365-05962008000500003&lng=en&nrm=iso&tlng=en