%0 Journal Article
%T Avalia£¿£¿o da efic¨¢cia e seguran£¿a do tacrolimo pomada 0,03% no tratamento da dermatite at¨®pica em pacientes pedi¨¢tricos
%A Gontijo
%A Bernardo
%A Duarte
%A Ida A. Gomes
%A Sittart
%A Jos¨¦ Alexandre de Souza
%A Pires
%A Mario Cezar
%A Takaoka
%A Roberto
%A Cestari
%A Silmara da Costa P.
%A Cestari
%A Tania Ferreira
%A Aun
%A Wilson Tartuce
%A Oliveira
%A Zilda Najjar P. de
%A La Scala
%A Cintia S. Kurokawa
%J Anais Brasileiros de Dermatologia
%D 2008
%I Sociedade Brasileira de Dermatologia
%R 10.1590/S0365-05962008000600003
%X background: tacrolimus ointment has been shown to be effective in treatment of atopic dermatitis. objectives: to evaluate the efficacy and safety of 0.03% tacrolimus ointment (protopic£¿) in pediatric patients with mild, moderate and severe atopic dermatitis. methods: open, non-comparative, multicentric study carried out in brazil. 174 patients (ages from two to 10) with mild to severe atopic dermatitis were included. patients were instructed to apply protopic£¿ twice a day for six weeks. primary efficacy criterion was clinical improvement > 90% assessed by the physician (clinical response global evaluation scale). other efficacy criteria included reduction of the eczema area severity index (easi), decrease of the affected body surface area (%bsa) and evaluation of the itching by the patients or their guardians (visual analogical scale). safety was evaluated by adverse events reported by patients and/or guardians or by investigators. results: thirty-three percent of patients showed clinical improvement > 90%. 45.5% of patients (1st week) decreased easi and 61.8% (6th week) (p<0,001). %bsa decreased 30.4% and 55.5% in the first and sixth week. improvement was also significant when measured by itching (p<0,001). most frequentadverse effects were: burning and itching. conclusion: 0.03% tacrolimus ointment is a safe and effective therapy for mild to severe atopic dermatitis in pediatric patients.
%K child
%K dermatitis
%K dermatitis
%K atopic
%K eczema
%K tacrolimus.
%U http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0365-05962008000600003&lng=en&nrm=iso&tlng=en