%0 Journal Article
%T Mecanismos de resistencia a antibi¨®ticos ¦Â-lact¨¢micos en Staphylococcus aureus
%A Castellano Gonz¨¢lez
%A Maribel J
%A Perozo-Mena
%A Armindo J
%J Kasmera
%D 2010
%I Scientific Electronic Library Online
%X s. aureus has shown a great power of adaptation to antimicrobial agents, acquiring, step-by-step, resistance to all available antibiotics for treatment of the infections it causes. s. aureus has three major mechanisms of resistance to ¦Â-lactam antibiotics: enzyme mediated (penicillinase or ¦Â-lactamase) by which the antibiotic is inactivated; intrinsic resistance, which is not due to drug inactivation and accounts for methicillin resistance; and modifications of penicillin-binding proteins (pbps). additionally, s. aureus can express the tolerance phenomenon, in which there is a dissociation of the inhibitory and killing actions of a-lactam antibiotics. of these, the most important mechanism is intrinsic resistance, which is probably more complex because several factors can affect its expression.
%K staphylococcus aureus
%K -lactam antibiotics
%K resistance mechanisms.
%U http://www.scielo.org.ve/scielo.php?script=sci_abstract&pid=S0075-52222010000100003&lng=en&nrm=iso&tlng=en