%0 Journal Article
%T Side-chain opening of steroidal sapogenins to form 22-oxocholestanic skeletons: An approach to analogues of the aglycone of the potent anticancer agent OSW-1
%A Fern¨¢ndez-Herrera
%A Mar¨ªa A.
%A Sandoval-Ram¨ªrez
%A Jes¨²s
%A Meza-Reyes
%A Socorro
%A Montiel-Smith
%A Sara
%J Journal of the Mexican Chemical Society
%D 2009
%I Sociedad Qu¨ªmica de M¨¦xico
%X the side-chain opening of 25r and 25s steroidal sapogenins to form 22-oxocholestanic skeletons is described. the transformation was produced under mild conditions providing high yields (70-87%), in a one pot procedure (some acetylated starting material is recovered). this methodology yields 17-deoxy-26-oxy analogues of the aglycone of the potent anticancer agent osw-1. all products were fully characterized by 1d and 2d nmr; the most representative displacements are briefly discussed.
%K steroidal sapogenins
%K acetolysis
%K aglycone
%K osw-1.
%U http://www.scielo.org.mx/scielo.php?script=sci_abstract&pid=S1870-249X2009000300007&lng=en&nrm=iso&tlng=en