%0 Journal Article
%T Mass spectrometry of 1,2,5-oxadiazole N-oxide derivatives: use of deuterated analogues in fragmentation pattern studies
%A Cerecetto
%A Hugo
%A Gonz¨˘lez
%A Mercedes
%A Seoane
%A Gustavo
%A Stanko
%A Carola
%A Piro
%A Oscar E.
%A Castellano
%A Eduardo E.
%J Journal of the Brazilian Chemical Society
%D 2004
%I Sociedade Brasileira de Qu¨Şmica, SBQ
%R 10.1590/S0103-50532004000200012
%X this paper reported on the study of fragmentation pattern in mass spectrometry of 1,2,5-oxadiazole n-oxide derivatives involving deuterium-labeled analogues to identify some critical fragmentations. a neutral ch2o loss from 3-hydroxymethyl-n2-oxide-4-phenyl-1,2,5-oxadiazole was confirmed with the corresponding mono-deuterated analogue. an oh loss, involving the oxygen of n-oxide, via b-h and d-h rearrangement, was clearly revealed from 3-(4-methylpiperazine-1-ylmethyl)-n2 -oxide-4-phenyl-1,2,5-oxadiazole using the adequate tetra-deuterated analogue. n-oxide isomer and deoxygenated analogues were also used to confirm the participation of the oxide moiety in the fragmentation process.
%K 1
%K 2
%K 5-oxadiazole n-oxide
%K d-labeled furoxan
%K mass fragmentation
%K ei/ms.
%U http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0103-50532004000200012&lng=en&nrm=iso&tlng=en