%0 Journal Article
%T Isoprenoid compounds from Euphorbia portlandica. X-ray structure of lupeportlandol, a new lupane triterpene
%A Madureira
%A Ana M.
%A Duarte
%A Maria Teresa
%A Piedade
%A Maria F¨¢tima M.
%A Ascenso
%A Jos¨¦ R.
%A Ferreira
%A Maria-Jos¨¦ U.
%J Journal of the Brazilian Chemical Society
%D 2004
%I Sociedade Brasileira de Qu¨ªmica, SBQ
%R 10.1590/S0103-50532004000500021
%X phytochemical survey of the me2co extracts of the whole dried plant euphorbia portlandica led to the isolation of a new pentacyclic triterpene alcohol, with the lupane skeleton, named lupeportlandol. its structure was established as 3a-hydroxy-19ah-lup-20(29)-ene. the known pentacyclic triterpene glutinol and the steroid b-sitostenone were also isolated. the characterization of the new compound and its acetylated derivative was based on spectroscopic methods and an x-ray diffraction analysis. lupeportlandol acetate was inactive in cytotoxicity assays in vitro against three human tumor cell lines: mcf-7 (breast cancer), nci-h460 (non-small cell lung cancer) and sf-268 (cns cancer).
%K euphorbia portlandica
%K triterpenes
%K steroids
%K lupane
%K x-ray diffraction.
%U http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0103-50532004000500021&lng=en&nrm=iso&tlng=en