%0 Journal Article
%T Evaluation of lipases in the desymmetrization of meso-exo-3,5-dihydroxymethylenetricyclo[5.2.1.0(2,6)]decane and the synthesis of chiral derivatives
%A Costa
%A Valentim E. U
%A Pohlmann
%A Adriana R
%A Sordi
%A Marli L. T. de
%J Journal of the Brazilian Chemical Society
%D 2004
%I Sociedade Brasileira de Qu¨Şmica, SBQ
%R 10.1590/S0103-50532004000100005
%X meso-exo-3,5-dihydroxymethylenetricyclo[5.2.1.0 2,6]decane was efficiently desymmetrized by the lipase from pseudomonas cepacia (ps-c 'amano' ii) in vinyl acetate in high yields (93%) and with excellent enantiomeric excesses (ee > 99% by chiral gc). chiral synthons for asymmetric synthesis were synthesized from this enantiopure compound.
%K lipases
%K enzymatic catalysis
%K desymmetrization
%K chiral compounds.
%U http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0103-50532004000100005&lng=en&nrm=iso&tlng=en