%0 Journal Article %T Enantioselective analysis of omeprazole in pharmaceutical formulations by chiral high-performance liquid chromatography and capillary electrophoresis %A Bonato %A Pierina S. %A Paias %A Fernanda O. %J Journal of the Brazilian Chemical Society %D 2004 %I Sociedade Brasileira de Qu¨Şmica, SBQ %R 10.1590/S0103-50532004000200025 %X we developed two sensitive and simple assay procedures based on high- performance liquid chromatography and capillary electrophoresis (ce) for the enantioselective analysis of omeprazole in pharmaceutical formulations. rac-omeprazole and (s)-omeprazole were extracted from commercially available tablets using methanol:naoh 2.5 mol l-1 (90:10, v/v). chiral hplc separation of omeprazole was obtained on a chiralpak ad column using hexane:ethanol (40:60, v/v) as the mobile phase and detection at 302 nm. the resolution of omeprazole enantiomers by ce was carried out using 3% sulfated b-cyclodextrin in 20 mmol l-1 phosphate buffer, ph 4.0 and detection at 202 nm. %K omeprazole %K enantiomer %K chiral hplc %K chiral ce %K pharmaceutical formulation. %U http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0103-50532004000200025&lng=en&nrm=iso&tlng=en