%0 Journal Article
%T Towards the total synthesis of Stawamycin. Synthesis of C11-C21 fragment
%A Dias
%A Luiz C.
%A Jardim
%A Luciana S. A.
%A Ferreira
%A Andrea A.
%A Soarez
%A Helena U.
%J Journal of the Brazilian Chemical Society
%D 2001
%I Sociedade Brasileira de Qu¨Şmica, SBQ
%R 10.1590/S0103-50532001000400003
%X the carbocyclic (c11-c21) fragment of stawamycin has been prepared by a sequence involving 11 steps (10% overall yield) from methyl (r)-(-)-3-hydroxy-2-methylpropionate. key steps are pd-catalyzed stille coupling reaction between a vinyl iodide and a vinylstannane followed by an intramolecular diels-alder cycloaddition reaction to afford the desired adduct as the major isomer together with three other possible adducts in 78% overall yield.
%K intramolecular diels-alder reaction
%K stille coupling
%K herpes virus inhibitor.
%U http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0103-50532001000400003&lng=en&nrm=iso&tlng=en