%0 Journal Article %T Synthesis of new 1,2,4-oxadiazoles carrying (1'S,2'S)-t-butyloxycarbonyl-1-amino-2- methyl-1-butyl and (1'S)-t-butyloxycarbonyl-1'-amino-1'-ethyl groups at C-5 %A Braga %A Vanildo Martins L. %A Melo %A Sebasti£¿o J. de %A Srivastava %A Rajendra M. %A Falc£¿o %A Emerson Peter da S. %J Journal of the Brazilian Chemical Society %D 2004 %I Sociedade Brasileira de Qu¨ªmica, SBQ %R 10.1590/S0103-50532004000400025 %X a facile and efficient synthesis of 3-aryl-5-[(1s)-t-butyloxycarbonyl-1-amino-(2 s)-methyl-1-butyl)]-1,2,4-oxadiazoles 4a-f and 3-phenyl-5-[(1s)-t-butyloxycarbonyl-1-amino-1-ethyl]-1,2,4 -oxadiazole 6 starting from arylamidoximes, n-t-boc-l-isoleucine and n-t- boc-l-alanine is decribed. the structures of the intermediates and final compounds have been deduced from spectroscopic data. %K chiral drugs %K 1 %K 2 %K 4-oxadiazoles %K arylamidoximes %K isoleucine %K alanine %K antiinflammatory %K antipyretic. %U http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0103-50532004000400025&lng=en&nrm=iso&tlng=en