%0 Journal Article
%T Synthesis of new 1,2,4-oxadiazoles carrying (1'S,2'S)-t-butyloxycarbonyl-1-amino-2- methyl-1-butyl and (1'S)-t-butyloxycarbonyl-1'-amino-1'-ethyl groups at C-5
%A Braga
%A Vanildo Martins L.
%A Melo
%A Sebasti£¿o J. de
%A Srivastava
%A Rajendra M.
%A Falc£¿o
%A Emerson Peter da S.
%J Journal of the Brazilian Chemical Society
%D 2004
%I Sociedade Brasileira de Qu¨ªmica, SBQ
%R 10.1590/S0103-50532004000400025
%X a facile and efficient synthesis of 3-aryl-5-[(1s)-t-butyloxycarbonyl-1-amino-(2 s)-methyl-1-butyl)]-1,2,4-oxadiazoles 4a-f and 3-phenyl-5-[(1s)-t-butyloxycarbonyl-1-amino-1-ethyl]-1,2,4 -oxadiazole 6 starting from arylamidoximes, n-t-boc-l-isoleucine and n-t- boc-l-alanine is decribed. the structures of the intermediates and final compounds have been deduced from spectroscopic data.
%K chiral drugs
%K 1
%K 2
%K 4-oxadiazoles
%K arylamidoximes
%K isoleucine
%K alanine
%K antiinflammatory
%K antipyretic.
%U http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0103-50532004000400025&lng=en&nrm=iso&tlng=en