%0 Journal Article
%T Potentiometric sensor for furosemide determination in pharmaceuticals, urine, blood serum and bovine milk
%A Santini
%A Alberto O.
%A Pezza
%A Helena R.
%A Sequinel
%A Rodrigo
%A Rufino
%A Jos¨¦ L.
%A Pezza
%A Leonardo
%J Journal of the Brazilian Chemical Society
%D 2009
%I Sociedade Brasileira de Qu¨ªmica, SBQ
%R 10.1590/S0103-50532009000100012
%X the construction, evaluation and analytical application of a potentiometric sensor, namely, pt|hg|hg2(fur)2|graphite, where fur stands for 4-chloro-n-furfuryl-5-sulphamoyl-anthranilate ion, are described. this electrode has a linear dynamic range between 5.0 ¡Á 10-7-1.0 ¡Á 10-2 mol l-1 with a near-nernstian slope of (-58.4¡À 0.9) mv decade-1 and a detection limit of 3.8 ¡Á 10-7 mol l-1. the potentiometric response is independent of the ph of the solution in the ph range 7.0-9.0. the electrode shows easy construction, low-cost, fast response time (within 10-20 s) and can be used for a period of 6 months without significant change in its performance characteristics. the proposed sensor displayed good selectivities over a variety of other anions (carboxylates and inorganic anions). application of this potentiometric sensor for the furosemide determination in pharmaceuticals, urine, blood serum and commercial milk samples is reported.
%K 4-cloro-n-furfuryl-5-sulphamoylanthranilate-sensitive electrode
%K potentiometry
%K pharmaceuticals
%K urine
%K human blood serum
%K bovine milk.
%U http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0103-50532009000100012&lng=en&nrm=iso&tlng=en