%0 Journal Article
%T The Polyoma Virus Large T Binding Protein p150 Is a Transcriptional Repressor of c-MYC
%A Chang Kyoo Sung
%A Hyungshin Yim
%A Hongcang Gu
%A Dawei Li
%A Erik Andrews
%A Sekhar Duraisamy
%A Cheng Li
%A Ronny Drapkin
%A Thomas Benjamin
%J PLOS ONE
%D 2012
%I Public Library of Science (PLoS)
%R 10.1371/journal.pone.0046486
%X p150, product of the SALL2 gene, is a binding partner of the polyoma virus large T antigen and a putative tumor suppressor. p150 binds to the nuclease hypersensitive element of the c-MYC promoter and represses c-MYC transcription. Overexpression of p150 in human ovarian surface epithelial cells leads to decreased expression, and downregulation to increased expression, of c-MYC. c-MYC is repressed upon restoration of p150 to ovarian carcinoma cells. Induction of apoptosis by etoposide results in recruitment of p150 to the c-MYC promoter and to repression of c-MYC. Analysis of data in The Cancer Genome Atlas shows negative correlations between SALL2 and c-MYC expression in four common solid tumor types.
%U http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0046486