%0 Journal Article
%T Antibacterial modified diketopiperazines from two ascidians of the genus Didemnum
%A Kossuga
%A Miriam H.
%A Lira
%A Simone P.
%A McHugh
%A Shayna
%A Torres
%A Yohandra R.
%A Lima
%A Bruna A.
%A Gon£¿alves
%A Reginaldo
%A Veloso
%A Katyuscya
%A Ferreira
%A Antonio G.
%A Rocha
%A Rosana M.
%A Berlinck
%A Roberto G. S.
%J Journal of the Brazilian Chemical Society
%D 2009
%I Sociedade Brasileira de Qu¨ªmica, SBQ
%R 10.1590/S0103-50532009000400014
%X the chemical investigation of the crude extract of an ascidian of the genus didemnumled to the isolation of the modified diketopiperazine rodriguesines a (1) and (2) as a mixture of homologues, which could be identified by analysis of spectroscopic data including ms/ms experiments. the investigation of a second didemnumsp. led to the isolation of n-acetyl-rodriguesine a (3) and n-acetyl-rodriguesine b (4). the absolute configuration of compounds 1and 2could be established by hydrolysis and marfey's analysis and comparison with literature data reported for compound 3, previously obtained as a synthetic product. the mixture of 1and 2displayed moderate antibiotic activity against a clinical isolate of streptococcus mutansand against s. mutansua159 and staphylococcus aureusatcc6538.
%K ascidian
%K marine
%K diketopiperazine
%K absolute configuration
%K antibiotic.
%U http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0103-50532009000400014&lng=en&nrm=iso&tlng=en