%0 Journal Article
%T Biotransformation of a tetrahydrofuran lignan by the endophytic fungus Phomopsis Sp.
%A Verza
%A Michelle
%A Arakawa
%A Nilton S.
%A Lopes
%A Norberto P.
%A Kato
%A Massuo J.
%A Pupo
%A M£¿nica T.
%A Said
%A Suraia
%A Carvalho
%A Ivone
%J Journal of the Brazilian Chemical Society
%D 2009
%I Sociedade Brasileira de Qu¨ªmica, SBQ
%R 10.1590/S0103-50532009000100029
%X the biotrasformation of the tetrahydrofuran lignan, (-)-grandisin, by the endophitic fungus phomopsis sp, obtained from viguiera arenaria, led to the formation of a new compound determined as 3,4-dimethyl-2-(4'-hydroxy-3',5'-dimethoxyphenyl)-5-methoxy-tetrahydrofuran. the metabolite was evaluated against the parasite trypanosoma cruzi, the causative agent of chagas's disease, and showed a trypanocidal activity (ic50 9.8 ¦̀mol l-1) similar to the natural precursor (ic50 3.7 ¦̀mol l-1).
%K biotransformation
%K 2
%K 5-diaryltetrahydrofuran
%K endophytic fungus
%K (-)-grandisin
%K trypanocidal activity.
%U http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0103-50532009000100029&lng=en&nrm=iso&tlng=en