%0 Journal Article
%T Chemical constituents from the roots of Spathelia excelsa and their antiprotozoal activity
%A Moreira
%A Wagner A. dos Santos
%A Lima
%A Maria da Paz
%A Ferreira
%A Antonio Gilberto
%A Ferreira
%A Izabel C. Piloto
%A Nakamura
%A Celso V.
%J Journal of the Brazilian Chemical Society
%D 2009
%I Sociedade Brasileira de Qu¨ªmica, SBQ
%R 10.1590/S0103-50532009000600014
%X phytochemical investigation from roots of spathelia excelsa yielded the chromones 10(2,3-epoxy-3-methylbutanyl) spatheliachromen and 10(2,3-dihydroxy-3-methylbutanyl) methoxyspatheliacromen (5-methoxyspatheliabischromen); limonoid deacetylspathelin and protolimonoid c-21-epimers 3¦Â-angeloyloxy-7¦Á,24,25-trihydroxy-21,23-oxide-14,18-cycloapotirucall-21-hemiacetal; the alkaloids 7,8-dimethoxyflindersin, casimiroin and n-methyl-4,7,8-trimethoxyquinolin-2(1h)-one, besides a mixture of ¦Â-sitosterol and stigmasterol. assays on promastigote forms of leishmania braziliensis, deacetylspathelin showed moderate activity; and on epimastigote forms of trypanossoma cruzi, 10(2,3-epoxy-3-methylbutanyl)spatheliachromen exhibited strong activity (ic50 = 11 ¦Ìg ml-1).
%K rutaceae
%K spathelia
%K trypanossoma cruzi
%K leishmania braziliensis.
%U http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0103-50532009000600014&lng=en&nrm=iso&tlng=en