%0 Journal Article
%T Asymmetric organocatalytic synthesis of ¦Â-Hydroxyynones with a quaternary carbon center under aqueous conditions
%A Kang
%A Guowei
%A Jiang
%A Jun
%A Liu
%A Hongxin
%A Wu
%A Huayue
%J Journal of the Brazilian Chemical Society
%D 2012
%I Sociedade Brasileira de Qu¨ªmica, SBQ
%R 10.1590/S0103-50532012000100002
%X the chiral tertiary amine thiourea catalyzed direct aldol reaction of unmodified methyl ynones under aqueous conditions is described. this procedure avoided the retro-aldol reaction of the ¦Â-hydroxyynone products, and tolerated both the isatin (1h-indole-2,3-dione) and the less active acyclic ¦Á-keto esters as acceptors, affording a structurally diverse array of ¦Â-hydroxyynones bearing a quaternary carbon center with moderate to good yields and enantioselectivities.
%K ¦Â-hydroxyynones
%K chiral thiourea
%K aldol reaction
%K aqueous condition.
%U http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0103-50532012000100002&lng=en&nrm=iso&tlng=en