%0 Journal Article
%T Biochemical and biological properties of Lonomia obliqua bristle extract
%A Chudzinski-Tavassi
%A A. M.
%A Carrijo-Carvalho
%A L. C.
%J Journal of Venomous Animals and Toxins including Tropical Diseases
%D 2006
%I Centro de Estudos de Venenos e Animais Pe?onhentos - CEVAP, Universidade Estadual Paulista - UNESP
%R 10.1590/S1678-91992006000200002
%X lonomia obliqua caterpillar is frequently seen in accidents with humans especially in the south of brazil. patients develop a hemorrhagic syndrome that can be treated with specific antilonomic serum. a consumptive coagulopathy was found to be the main cause of bleeding complications observed in patients after contact with l. obliqua. studies revealed that l. obliqua caterpillar bristle extract (locbe) displays a procoagulant activity that leads to intravascular thrombin formation, resulting in a special form of disseminated intravascular coagulation (dic). fibrinolysis seems to be secondary to the fibrin production, since no direct fibrinolytic activity was found in locbe. two procoagulant toxins, a factor x activator (losac) and a prothrombin activator (lopap), were isolated from locbe and characterized. infusion of lopap into experimental animals triggered a condition similar to that observed in human envenomation.
%K lonomia obliqua
%K lonomia obliqua bristle extract
%K hemorrhagic syndrome
%K disseminated intravascular coagulation.
%U http://www.scielo.br/scielo.php?script=sci_abstract&pid=S1678-91992006000200002&lng=en&nrm=iso&tlng=en