%0 Journal Article
%T Scorpions from the primeval subgenus Archaeotityus produce putative homologs of Tityus serrulatus toxins active on voltage-gated sodium channels
%A Borges
%A A
%A Jowers
%A MJ
%A B¨®noli
%A S
%A De Sousa
%A L
%J Journal of Venomous Animals and Toxins including Tropical Diseases
%D 2012
%I Centro de Estudos de Venenos e Animais Pe?onhentos - CEVAP, Universidade Estadual Paulista - UNESP
%R 10.1590/S1678-91992012000400012
%X it has been proposed that the subgenus archaeotityus comprises the most ancient species group within the medically important scorpion genus tityus. cdna encoding sodium-channel active toxins from the type species of this subgenus, tityus clathratus (central venezuela), have been isolated and sequenced. two cdnas were retrieved that encoded 61 amino acid-long putative neurotoxins named tcl1 and tcl2. sequence identity was highest (87%) when both were compared with ¦Â-toxin ts1 from the brazilian scorpion tityus serrulatus and its homologs from t. bahiensis, t. stigmurus, and t. costatus. a bayesian analysis indicated statistical support for the grouping of t. clathratus tcl1 and tcl2 with brazilian gamma-like ¦Â-toxins, reinforcing previous phylogenetic studies which suggested an evolutionary relationship between the subgenus archaeotityus and scorpion species inhabiting southeast south america belonging to the subgenus tityus.
%K archaeotityus
%K scorpions
%K scorpion toxins
%K tityus
%K tityus clathratus
%K tityus serrulatus.
%U http://www.scielo.br/scielo.php?script=sci_abstract&pid=S1678-91992012000400012&lng=en&nrm=iso&tlng=en