%0 Journal Article
%T Measurement of IL-10 serum levels in BALB/c mice treated with beta-1,3 polyglucose or sulfadiazine and acutely infected by Toxoplasma gondii
%A Picka
%A M. C. M.
%A Calvi
%A S. A.
%A Lima
%A C. R. G.
%A Santos
%A I. A. T.
%A Marcondes-Machado
%A J.
%J Journal of Venomous Animals and Toxins including Tropical Diseases
%D 2005
%I Centro de Estudos de Venenos e Animais Pe?onhentos - CEVAP, Universidade Estadual Paulista - UNESP
%R 10.1590/S1678-91992005000400012
%X acute infection by toxoplasma gondii leads to suppression of cell-mediated immunity, facilitating chronic infection. one of the causes of immunosuppression is interleukin-10 (il-10) production. glucan is used to stimulate phagocytosis. our objective was to study il-10 induction in male balb/c mice with acute t. gondii btu-2 strain infection, glucan immunostimulation, and sulfadiazine treatment. animals were distributed into 7 groups: g1: infected with t. gondii; g2: infected with t. gondii and treated with sulfadiazine; g3: infected with t. gondii and immunostimulated with glucan; g4: infected with t. gondii, immunostimulated with glucan, and treated with sulfadiazine; g5: imunostimulated with glucan; g6: treated with saline; and g7: treated with sulfadiazine. il-10 levels were determined by elisa; the highest levels were found in g2, g3 and g4, and the lowest in g1 (p<0.001). groups g1 to g5 and g7 had substantially higher levels than g6 (p<0.001). in this study, the highest il-10 levels were found in groups treated with glucan.
%K toxoplasma gondii
%K interleukin-10
%K glucan
%K immune response
%K sulfadiazine.
%U http://www.scielo.br/scielo.php?script=sci_abstract&pid=S1678-91992005000400012&lng=en&nrm=iso&tlng=en