%0 Journal Article
%T Occurrence of pneumocystis pneumonia in hiv-infected patients and the interference of the highly active antiretroviral therapy
%A Barbosa
%A A. N.
%A Souza
%A L. R.
%J Journal of Venomous Animals and Toxins including Tropical Diseases
%D 2008
%I Centro de Estudos de Venenos e Animais Pe?onhentos - CEVAP, Universidade Estadual Paulista - UNESP
%R 10.1590/S1678-91992008000100012
%X from the beginning of the aids epidemic, pneumocystis pneumonia (pcp) has been distinguished as one of the most frequent opportunistic diseases with high morbid-mortality. as from 1996, the advent of the highly active antiretroviral therapy (haart) has changed the characteristics of such epidemic by reducing its related diseases and, as a result, aids-related mortality. with the purpose to estimate pcp occurrence and haart interference, 376 hiv-infected or aids patients were studied from january 1992 to december 2002. among them, 58 (15.5%) pcp cases were found. there was a higher occurrence of pcp in the group of patients in which haart was not used, with 40 (69.0%) of the episodes. as regards the studied period, a tendency to a linear reduction in annual pcp incidence was observed. the mean of t cd4+ lymphocytes in the patients with pcp (117 cells/mm3) was significantly lower when compared to that of the other individuals (325 cells/mm3). therefore, this study suggests a temporal reduction in pcp occurrence related to haart use with higher t cd4+ lymphocyte counts. nevertheless, this opportunistic infection still shows significant incidence in aids patients. (nct00516581).
%K aids
%K pneumocystis pneumonia
%K antiretroviral treatment
%K t cd4+ lymphocytes.
%U http://www.scielo.br/scielo.php?script=sci_abstract&pid=S1678-91992008000100012&lng=en&nrm=iso&tlng=en