%0 Journal Article
%T Scorpion (Buthus tamulus) venom toxicity on cardiopulmonary reflexes involves kinins via 5-HT3 receptor subtypes
%A BAGCHI
%A S.
%A DESHPANDE
%A S. B.
%J Journal of Venomous Animals and Toxins
%D 2001
%I Scientific Electronic Library Online
%R 10.1590/S0104-79302001000100003
%X the mechanisms underlying the action of indian red scorpion buthus tamulus (bt) venom-induced augmentation of cardiopulmonary reflexes elicited by intravenous injection of 5-ht were examined in urethane anaesthetized rats. the 5-ht produced a concentration-dependent increase in time-response area of bradycardiac response, with the responses at submaximal concentrations shifted to the left after exposure to bt venom (20 ¦Ìg/kg, iv). aprotinin (6000 kallikrein inactivating unit, iv) as such had no effect on 5-ht reflex responses (bradycardia, hypotension, and apnea), but blocked the venom-induced reflex augmentation. while ondansetron (10 ¦Ìg/kg, iv) completely blocked the 5-ht reflex responses, these reappeared partially after venom exposure (20 ¦Ìg/kg). exposure to bradykinin (50 ¦Ìg/kg, iv) for 30 min also augmented the 5-ht-induced reflex responses similar to venom. the bradykinin-induced augmentation was also blocked by ondansetron. results indicate that the venom-induced augmentation of cardiopulmonary reflexes is mediated through kinins sensitizing 5-ht3 receptor subtypes.
%K bezold-jarisch reflex
%K aprotinin
%K bradykinin
%K indian red scorpion
%K ondansetron
%K buthus tamulus
%K kinins
%K 5-ht3 receptors
%K cardiopulmonary reflexes.
%U http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0104-79302001000100003&lng=en&nrm=iso&tlng=en