%0 Journal Article
%T Different levels of MT-I/II between patients with MTLE with or without seizure generalization: does hippocampal MT-I/II affects seizure spread, or does seizure spread promotes differential expression of MT-I/II?
%A Peixoto-Santos
%A Jos¨¦ Eduardo
%A Galvis-Alonso
%A Orfa Yineth
%A Velasco
%A Tonicarlo R.
%A Kandratavicius
%A Ludmyla
%A Assirati Jr
%A JoŁżo Alberto
%A Carlotti
%A Carlos Gilberto
%A Scandiuzzi
%A Renata Caldo
%A Serafini
%A Luciano Neder
%A Leite
%A JoŁżo Pereira
%J Journal of Epilepsy and Clinical Neurophysiology
%D 2012
%I Liga Brasileira de Epilepsia
%R 10.1590/S1676-26492012000100005
%X in the central nervous system, zinc is released along with glutamate during neurotransmission and, in excess, can promote neuronal death. experimental studies have shown that metallothioneins i/ii (mt-i/ii), which chelate free zinc, can affect seizures and reduce neuronal death after status epilepticus. our aim was to evaluate the expression of mt-i/ii in the hippocampus of patients with temporal lobe epilepsy (tle). hippocampi from patients with pharmacoresistant mesial temporal lobe epilepsy (mtle) were evaluated for expression of mt-i/ii and for neuronal, astroglial, and microglial populations. compared to control cases, mtle group displayed widespread increase in mt-i/ii expression, astrogliosis and reduced neuronal population. mt-i/ii levels did not correlate with any clinical variables, but patients with secondary generalized seizures (sgs) had less mt-i/ii than patients without sgs. in conclusion, mt-i/ii expression was increased in hippocampi from mtle patients and our data suggest that it may be associated with different seizure spread patterns.
%K metallothioneins
%K zinc homeostasis
%K gliosis
%K epilepsy
%K neuronal density.
%U http://www.scielo.br/scielo.php?script=sci_abstract&pid=S1676-26492012000100005&lng=en&nrm=iso&tlng=en