%0 Journal Article
%T Sildenafil no tratamento da hipertens£¿o pulmonar associada a l¨²pus eritematoso sist¨ºmico e s¨ªndrome antifosfolip¨ªdio
%A Souza
%A Eduardo Jos¨¦ do Ros¨¢rio e
%A Garib
%A Junia Rios
%A Garib
%A Nasim Michel
%A P¨¢dua
%A Paulo Madureira de
%J Jornal de Pneumologia
%D 2003
%I Scientific Electronic Library Online
%R 10.1590/S0102-35862003000500009
%X severe pulmonary hypertension is a debilitating disease with short life expectancy that often affects young people. pleuropulmonary complications of systemic lupus erythematosus occur in 50-70% of patients. severe symptomatic pulmonary hypertension in systemic lupus erythematosus is rare and carries a bad prognosis because a fatal outcome can occur within months. the authors describe, for the first time, a patient with systemic lupus erythematosus with severe pulmonary hypertension and secondary antiphospholipid syndrome who responded favorably to oral sildenafil, after unsuccessful use of prednisone, intravenous cyclophosphamide, warfarin and diltiazem.
%K vasodilator agents [therapeutic use]
%K lupus erythematosuos systemic
%K antiphospholipid antibodies
%K phosphodiesterase inhibitors.
%U http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0102-35862003000500009&lng=en&nrm=iso&tlng=en