%0 Journal Article
%T Innovaciones en la compresi¨®n de los efectos de la isquemia fr¨ªa en el injerto renal
%A Lled¨® Garc¨ªa
%A E.
%A Berenguer Garc¨ªa
%A I.
%A Rodr¨ªguez Mart¨ªnez
%A D.
%A Pedemonte
%A G.
%A Hern¨¢ndez Fern¨¢ndez
%A C.
%A Ca£¿izo L¨®pez
%A J.F. del
%J Actas Urol¨®gicas Espa£¿olas
%D 2005
%I Scientific Electronic Library Online
%R 10.4321/S0210-48062005000400010
%X cold ischemia is the best known method to preserve kidneys for transplant. however, it produces several detrimental effects. first, cellular necrosis. secondarily, during the hypothermic period a mithocondrial injury process develops which makes the cell entering a pre-apoptotic state. this apoptosis occurs definitively in the reperfusion. preservation solutions currently available are not perfect and are not able to avoid cold-related cell injuries. the adition of certain substances to uw solution (desferrioxamine) has shown experimentally a reduction in mitochondrial cold-related lesions. isolated hypothermic kidney perfusion reduces initial graft dysfunction about 20% in comparison to hypothermic storage. this fact relates to important either economical as functional consequences.
%K renal transplant
%K cold ischemia
%K renal preservation.
%U http://scielo.isciii.es/scielo.php?script=sci_abstract&pid=S0210-48062005000400010&lng=en&nrm=iso&tlng=en