%0 Journal Article %T The anticancer agent PB-100, selectively active on malignant cells, inhibits multiplication of sixteen malignant cell lines, even multidrug resistant %A Beljanski %A Mirko %J Genetics and Molecular Biology %D 2000 %I Sociedade Brasileira de Gen¨¦tica %R 10.1590/S1415-47572000000100005 %X the plant-derived anticancer agent pb-100 selectively destroys cancer cells, even when multidrug resistant; yet, it does not inhibit normal (non-malignant) cell multiplication. testing of pb-100 on sixteen malignant cell lines, several multidrug resistant, as well as on five normal cell lines, confirmed our previous results. flavopereirine and dihydroflavopereirine, the active principles of pb-100, were chemically synthesized and displayed the same selectivity for tumor cells as the purified plant extract, being active at even lower concentrations. %U http://www.scielo.br/scielo.php?script=sci_abstract&pid=S1415-47572000000100005&lng=en&nrm=iso&tlng=en