%0 Journal Article
%T Molecular characterization of MHC-DRB cDNA in water buffalo (Bubalus bubalis)
%A Naskar
%A Soumen
%A Deb
%A Sitangsu M.
%A Niranjan
%A Saket K.
%A Kumar
%A Subodh
%A Sharma
%A Deepak
%A Sakaram
%A Durgam
%A Sharma
%A Arjava
%J Genetics and Molecular Biology
%D 2012
%I Sociedade Brasileira de Gen¨¦tica
%R 10.1590/S1415-47572012005000013
%X in the present study, water buffalo mhc (bubu)-drb cdna was cloned and characterized. the 1022 base long-amplified cdna product encompassed a single open reading frame of 801 bases that coded for 266 amino acids. the bubu-drb sequence showed maximum homology with the bola-drb3*0101 allele of cattle. a total of seven amino acid residues were found to be unique for the bubu-drb sequence. the majority of amino acid substitutions was observed in the ¦Â1 domain. residues associated with important functions were mostly conserved. water buffalo drb was phylogenetically closer to goat drb*a.
%K water buffalo
%K cdna
%K drb
%K mhc
%K phylogeny.
%U http://www.scielo.br/scielo.php?script=sci_abstract&pid=S1415-47572012000100013&lng=en&nrm=iso&tlng=en