%0 Journal Article
%T Monosomy 7 in donor cell-derived leukemia after bone marrow transplantation for severe aplastic anemia: report of a new case and review of the literature
%A Otero
%A Luize
%A Souza
%A Daiane Correa de
%A Tavares
%A Rita de C¨¢ssia
%A Gomes
%A Bernadete Evangelho
%A Padilha
%A Telma Fran£¿a
%A Bouzas
%A Luiz Fernando
%A Fernandez
%A Teresa de Souza
%A Abdelhay
%A Eliana
%J Genetics and Molecular Biology
%D 2012
%I Sociedade Brasileira de Gen¨¦tica
%R 10.1590/S1415-47572012005000056
%X monosomy 7 arises as a recurrent chromosome aberration in donor cell leukemia after hematopoietic stem cell transplantation. we report a new case of donor cell leukemia with monosomy 7 following hla-identical allogenic bone marrow transplantation for severe aplastic anemia (saa). the male patient received a bone marrow graft from his sister, and monosomy 7 was detected only in the xx donor cells, 34 months after transplantation. the patient's bone marrow microenvironment may have played a role in the leukemic transformation of the donor hematopoietic cells.
%K monosomy 7
%K donor cell leukemia
%K bone marrow transplantation
%K severe aplastic anemia.
%U http://www.scielo.br/scielo.php?script=sci_abstract&pid=S1415-47572012000500004&lng=en&nrm=iso&tlng=en