%0 Journal Article
%T Polymorphisms of arylamine N-acetyltransferase2 and risk of lung and colorectal cancer
%A Mahasneh
%A Amjad
%A Jubaili
%A Amal
%A El Bateiha
%A Ahmed
%A Al-Ghazo
%A Mohammad
%A Matalka
%A Ismail
%A Malkawi
%A Mousa
%J Genetics and Molecular Biology
%D 2012
%I Sociedade Brasileira de Gen¨¦tica
%R 10.1590/S1415-47572012005000074
%X the arylamine n-acetyltransferase 2 (nat2) enzymes detoxify a wide range of naturally occurring xenobiotics including carcinogens and drugs. point mutations in the nat2 gene result in the variant alleles m1 (nat2 *5a), m2 (nat2*6a), m3 (nat2*7) and m4 (nat2 *14a) from the wild-type wt (nat2 *4) allele. the current study was aimed at screening genetic polymorphisms of nat2 gene in 49 lung cancer patients, 54 colorectal cancer patients and 99 cancer-free controls, using pcr-rflp. there were significant differences in allele frequencies between lung cancer patients and controls in the wt, m2 and m3 alleles (p < 0.05). however, only m2 and m3 allele frequencies were different between colorectal cancer patients and controls (p < 0.05). there was a marginal significant difference in the distribution of rapid and slow acetylator genotypes between lung cancer patients and controls (p = 0.06 and p = 0.05, respectively), but not between colorectal cancer patients and controls (p = 1.0 and p = 0.95, respectively). risk of lung cancer development was found to be lower in slow acetylators [odds ratio (or): 0.51, 95% confidence interval (95% ci): 0.25, 1.02, p-value = 0.07]. no effect was observed in case of colorectal cancer. our results showed that nat2 genotypes and phenotypes might be involved in lung cancer but not colorectal cancer susceptibility in jordan.
%K nat2
%K lung cancer
%K colorectal cancer
%K polymorphisms.
%U http://www.scielo.br/scielo.php?script=sci_abstract&pid=S1415-47572012000500003&lng=en&nrm=iso&tlng=en