%0 Journal Article
%T New evidence for balancing selection at the HLA-G locus in South Amerindians
%A Veit
%A Tiago Degani
%A Cazarolli
%A Juciana
%A Salzano
%A Francisco Mauro
%A Schiengold
%A Marion
%A Chies
%A Jos¨¦ Artur Bogo
%J Genetics and Molecular Biology
%D 2012
%I Sociedade Brasileira de Gen¨¦tica
%R 10.1590/S1415-47572012000600005
%X hla-g is a non-classical hla (human leukocyte antigen) molecule characterized by limited tissue distribution under normal physiological conditions and low variability at both dna and protein levels. several studies suggest that hla-g could play a role, as an immunoregulatory molecule, in situations as diverse as transplantation, cancer, viral infections and inflammatory diseases. a total of 237 individuals from 21 south american tribes speaking nine different linguistic families were studied in relation to the 14 bp insertion/deletion polymorphism at the hla-g gene. a consistent (seven in nine) excess of heterozygosity in samples classified by language was obtained. our data supply evidences for balancing selection acting at the hla-g 14 bp indel region. enhanced fetal survival in a pathogen-rich environment may account for these findings.
%K hla-g 14 bp indel
%K balancing selection
%K amerindians
%K pathogen resistance.
%U http://www.scielo.br/scielo.php?script=sci_abstract&pid=S1415-47572012000600005&lng=en&nrm=iso&tlng=en