%0 Journal Article
%T Recombinant human granulocyte-macrophage colony-stimulating factor: effect of glycosylation on pharmacokinetic parameters
%A Marini
%A Guillermo
%A Forno
%A Guillermina
%A Kratje
%A Ricardo
%A Etcheverrigaray
%A Marina
%J Electronic Journal of Biotechnology
%D 2007
%I Pontificia Universidad Cat¨®lica de Valpara¨ªso
%X the pharmacokinetic behaviour of the non-glycosylated, bacterially-derived recombinant human granulocyte-macrophage colony-stimulating factor (rhgm-csf) and the glycosylated mammalian product was studied after intra and extra vascular administration of a single dose in rodents. each route of administration gave a different rhgm-csf concentration-time profile. after extra vascular administration of equivalent doses, a higher peak concentration and faster elimination were observed in the group treated with the e. coli-derived cytokine. the faster elimination resulted in a return to pre-treatment plasma levels after 12 hrs, versus 48 hrs following the administration of glycosylated rhgm-csf. after intravascular administration, clearance of rhgm-csf was significantly decreased by the presence of carbohydrates. non-significant differences in the terminal phase of the biphasic kinetics were found, but the distribution phase was significantly longer for the glycosylated form
%K glycosylation
%K pharmacokinetic parameters
%K rhgm-csf.
%U http://www.scielo.cl/scielo.php?script=sci_abstract&pid=S0717-34582007000200011&lng=en&nrm=iso&tlng=en