%0 Journal Article
%T Mixomas card¨ªacos: estudio morfol¨®gico e inmunohistoqu¨ªmico de 50 biopsias
%A Scholz
%A Jannete
%A Su¨¢rez
%A Claudia
%A Mota
%A Jos¨¦ David
%J Gaceta M¨¦dica de Caracas
%D 2007
%I Scientific Electronic Library Online
%X myxomas are the most frequent primary tumors of the heart. fifty cardiac biopsies of myxomas were analyzed by histopathology, in 24 of which, the immunohistochemical was done. patients (m/f: 19/31) whose ages were between second and seventh decade of life, presented varied sintomatology, were operated with the diagnosis of tumor and/or intracardiac mass. the most frequent location of myxomas was in left (86.0 %) and right (8.0 %) auricles. macrocospically, they presented gelatinous and mixoide aspect, one single case was petrified. they measured between 3 and 10 cm and 50.0 % were pediculate. to the light microscope, they were characterized by: isolated cells or forming vascular structures (94.0 %), seudopapilars (54.0 %) and pseudo glandulars (4.0 %); abundant mixoide matrix with inflammatory cells (96.0 %), hemorrhage (94.0 %), nodules of gamna-gandi (30.0 %) and calcifications (18.0 %). the immunohistochemical study revealed: positive marker in the tumorlike cells: vimentine (100.0 %), cd34 (83.0 %), actine smooth muscle (37.0 %) desmine (17.0 %). the marker for s-100 were negative and the cytoqueratine (a1/ae3) was positive in a single case with glandular differentiation. conclusions: on the base of the immunohistochemical study, we considered that evidences exist that support the mesenquimal origin of the tumor with predominant differentiation towards the endotelial line.
%K key words
%K cardiac myxomas
%K cardiac tumors
%K immunohistochemical.
%U http://www.scielo.org.ve/scielo.php?script=sci_abstract&pid=S0367-47622007000200005&lng=en&nrm=iso&tlng=en