%0 Journal Article
%T El Ca2+ y los esfingol¨ªpidos como moduladores de la apoptosis y el c¨¢ncer
%A Pimentel
%A Adriana A
%A Benaim
%A Gustavo
%J Investigaci¨®n Cl¨ªnica
%D 2012
%I Scientific Electronic Library Online
%X ca2+ is a second messenger which regulates many functions directly related with cancer such as proliferation, differentiation and apoptosis. the intracellular ca2+ concentration ([ca2+]i) is finely regulated by several mechanisms, among them ionic channels, the endoplasmic reticulum ca2+-atpase (serca), the plasma membrane calcium pump (pmca) and the mitochondrial ca2+ transport. in cancer, the tumour cell proliferates without control since the capacity to recognize apoptotic signals has been lost. the apoptosis is regulated by changes in several proteins, as caspases and the bcl-2 family members, among others. additionally, the ¡°reticulum stress¡±, promoted by the accumulation and aggregation of unfolded proteins in the interior of the endoplasmic reticulum (er), ussually leads to apoptosis. the ¡°reticulum stress¡± can be induced by several agents, remarkably with thapsigargin, a selective inhibitor of the serca, which in turn induces a large increment in [ca2+]i, leading to apoptosis. as a consequence, currently, derivatives of thapsigargin are successfully been assayed as anti-neoplastic agents. ca2+ is then transferred to the mitochondria, where it is known to constitute a main apoptotic signal. on the other hand, several sphingolipids, such as ceramide and sphingosine, and their phosphorylated derivatives ceramide-1-phosphate and sphingosine-1-phosphate, directly involved in the [ca2+]i regulation, are also recognized as signal messengers related with cancer processes. in this review we discuss new evidences on the effect of several sphingolipids in the intracellular ca2+ homeostasis and its relationship with apoptosis and cancer.
%K cancer
%K ca2+
%K sphingolipids
%K apoptosis
%K serca inhibitors.
%U http://www.scielo.org.ve/scielo.php?script=sci_abstract&pid=S0535-51332012000100009&lng=en&nrm=iso&tlng=en